The Homestar Runner video features many of the H*R characters created by Mike and Matt Chapman. Clicking on the text "Directed by Strong Sad & The Cheat" at the beginning of the video loads an audio commentary by the H*R characters. It doesn't have much to do with TMBG lore, but they do refer to Them as "Super Giants," "Supreme Giants," and "That one right there with the glasses", and make continual references to the skull.
At the November 18, 2006 show in Nyack, the song was announced as "Too Physically Weak!" and it ended with alternate lyrics: "Yeah! I'm physically weak in this experimental film..." The reason for this change is likely because it was the final song of the show's second encore. The band was indeed, tired and "physically weak".
When this song is played live, Flansburgh has a tendency to yell "Guitar!" in a falsetto voice before the solo, reminiscent of Justin Hawkins of The Darkness in "I Believe in a Thing Called Love".