In April 2006, Dunkin' Donuts began their America Runs on Dunkin' ad campaign, featuring multiple commercials with original songs by none other than They Might Be Giants. (It makes perfect sense, really. TMBG is known for being a coffee-fueled band.) A few more commercials premiered up until June, when round 1 of the campaign had ended. In September and October of 2006, round 2 began, bringing six new commercials (with the ending lines spoken by John Goodman). In January 2008, two new commercials began airing.
A few years later, John Flansburgh had this to say of the project:
Through the mid-00s TMBG recorded a couple dozen songs for television and radio commercials for Dunkin Donuts. It was an impossibly open-ended assignment and easily the most fun we’ve ever had working for television folks. The creative team there would often just give us small sets of words to work off of, and ["Karate!"] might be the most extreme example—and yet it turned into something far more universal than one might imagine.
| Ad Name | Length | First Aired | Watch |
| Round 1: | |||
| A Ton Of Stuff | 0:30 | April 2006 |
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| Early Fishin' | 0:30 | April 2006 |
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| Lunch Is Over | 0:30 | April 2006 |
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| Lunch Is Over (Radio Version) | 0:30 | April 2006 | Radio only |
| Pleather | 0:30 | April 2006 |
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| Things I Like To Do | 1:00 | April 2006 |
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| Tree | 0:30 | April 2006 |
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| I'm In A Rut | 0:30 | May 2006 | Radio only |
| One Billion Degrees | 0:30 | May 2006 |
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| Karate! | 0:25 | June 2006 |
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| Round 2: | |||
| Human Interest | 0:30 | September 2006 |
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| Alarm Clock Catastrophe | 0:30 | October 2006 |
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| Auto Pilot | 0:30 | October 2006 |
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| Fritalian | 0:30 | October 2006 |
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| Got Getting Up So Down | 0:30 | October 2006 | Radio only |
| Job Interview | 0:30 | October 2006 |
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| Lefty Loosey | 0:30 | October 2006 |
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| One Car Motorcade | 1:00 | Unaired | N/A |
| Round 3: | |||
| Bleachers | 0:30 | January 2008 |
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| Steps | 0:30 | January 2008 |
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| All Night Blowout | 0:30 | April 2008 |
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| Moving | 0:30 | April 2008 |
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