Interpretations:I'm Sick (Of This American Life)

From This Might Be A Wiki

Written for the radio show, "This American Life," the lyrics are very cryptic and disjointed. The value of human sacrifice seems to be the only direct reference to American Life. Perhaps the cold, combative, inhuman nature of American Life has numbed the singer, and his ability to interact sucessfully with the other Americans. After being forced to learn the value of human sacrifice, he is tired and sick of the whole scene. --Pandastan 22:10, 16 Jan 2006 (EST)

And the show's host is Ira Glass, a name which they were clearly trying to get into the song via the "two glass eyes" line.