The They Might Be Giants Podcast is not only a collection of songs organized by the band, it is also, through narrator patters and short spoken segments, a host to a slew of fictional characters. Listed below — in order of appearance — are the names, descriptions, and supposed true identities of the fake personas whose voices appear in the podcast.
|Character name||Description||Voiced by*||Appears in|
|Cecil Portesque||The host of TMBG's Podcast||John Flansburgh (Except 1A, John Linnell)||Multiple|
|The Deranged Millionaire||Appeared out of contractual obligation, due to TMBG's completion of the Venue Songs challenge||John Hodgman||Podcast 3A|
|David Remnikopf||Contributed "computer assisted, three-dimensional special effects" to the song "(She Was A) Hotel Detective In The Future"||John Linnell||Podcast 5A|
|Anne Hathaway||Foley artist for "(She Was A) Hotel Detective In The Future"||John Linnell||Podcast 5A|
|Julian Dufy||TMBG's "longtime engineer and archivist"||John Flansburgh||Podcast 10A, Podcast 11A|
|Evan and Anderson||Band members of "They Must Be Giants"||John Flansburgh||Podcast 26A|
|Squeeky||Temporary host, filling in for Cecil||John Flansburgh||Podcast 53|
*With the exception of John Hodgman, voice actors' true identities have been determined through original research using audio samples.