This American Life is a public radio show based at WBEZ in Chicago and distributed by Public Radio International.
Dial-A-Song was featured in the episode Telephone and TMBG performed live in the episode What You Lookin' At?. Ira Glass, host of the show, also spoke of his fandom in Gigantic (A Tale Of Two Johns).
Also notable is leading contributor Sarah Vowell, who is an avid fan of They Might Be Giants, and for whom TMBG wrote a song based on the title of the show, I'm Sick (Of This American Life).